Valencia are rated as one of the favourites to win the Europa League this season but the Spanish giants will first have to get past PSV Eindhoven if they wish have any chance of claiming the European title (Valencia 8/13, draw 14/5, PSV 9/2 Match Betting).
Were it not for Real Madrid and Barcelona, Los Che (7/1 Europa League outright) would be the premier team in La Liga and the outfit from the Mestalla are deservedly one of the favourites to lift the trophy outside of the Manchester giants United and City.
With the likes of Ever Banega pulling the strings in the midfield and Roberto Soldado banging in the goals up front, Valencia have a host of players that will be looking to cause PSV problems on Thursday night.
Manager Unai Emery had to negotiate his side past the challenges Stoke City presented them in the last round and despite getting drawn into a niggly second-leg at the Mestalla, Valencia managed to outplay the Potters.
PSV will pose very different problems for the Spanish tactician as they look to bounce back from their 6-2 defeat at the hands of FC Twente in the Eredivisie on Sunday.
The Rood-Witten did see off Turkish outfit Trabzonspor in the last round of the Europa League and will be no pushovers when they make the trip to Spain.
However Valencia should prove to be too strong at home, as they have been for much of the domestic season, and put themselves in a strong position before the return trip to the Netherlands.
Twente will still be flying high after their convincing victory over PSV, as they look ahead to their matchup with Schalke 04 at De GrolschVeste (Twente 5/4, draw 9/4, Schalke 21/10 Match Betting).
The Reds are currently sitting in second place in the Eredivisie with a game in hand over league leaders AZ Alkmaar and will be confident of getting a result against their German opponents.
They might well be taking on Schalke at a good time as the Bundesliga side have suffered defeats in their last two domestic outings against Bayern Munich and Freiburg.
Dutch striker Klaas-Jan Huntelaar will be looking to get one over on Twente on Thursday, if he has managed to shake off the concussion he sustained in the 3-2 victory over England.
With the kind of form Schalke are in at the moment, Twente might just edge this one on home soil, in what should be a closely fought contest.
Fellow Dutch side Alkmaar also face a tough matchup when they take on Udinese, who have come on leaps and bounds in Serie A this season (Alkmaar 6/5, draw 11/5, Udinese 12/5 Match Betting).
Udinese (20/1 Europa League outright) have seen off the likes of Celtic and PAOK Salonika in previous encounters in this competition and could be a dark horse for the Europa League title in 2012.
Frontman Antonio Di Natale is a prolific striker and he will certainly be someone the AZ defence will have to look out for.
Despite topping the Eredivisie and looking in good form, Udinese could get the win in Holland to take back with them to the Stadio Friuli.
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